Cortical Connections Conference 2019

Full Program and Speaker List
The Cortical Connections Conference is a scientific meeting about developmental anomalies of cortical connectivity (specifically the corpus callosum). Conference speakers include scientists and clinicians from around the world; leading experts from the fields of developmental neuroscience, laboratory genetics, clinical genetics, paediatric neurology, neuroimaging and neuropsychology. 

The program consists of a series of brief presentations arranged in general progression from cellular & molecular studies, to neural diagnostics in humans, and finally to higher-level cognitive and behavioral issues related to anomalies of cortical connectivity. 

Registration closes when 180 people register or on May 15 (whichever comes first).
Registration must be completed online in Eventbrite, including payment of a 100 € per person for professionals and 35 € per person for students.

La conférence sur les connections corticales est une réunion scientifique sur les anomalies du développement de la coonectivité corticale et spécifiquement du corps calleux. Les intervenants sont des scientifiques et des cliniciens venant du monde entier : des experts en neuroscience développementale, génétique, neuropédiatrie, imagerie cérébrale, et neuropsychologie.
Le programme consiste en une série de présentations organisées de manière progressive : des études moléculaires et cellulaires au diagnostic chez l'homme, et enfin les différentes atteintes cognitives et comportementales dues à ces anomalies.
Les inscriptions seront cloturées le 15 Mai 2019, ou dès que le nombre maximal d’invités sera atteint (180 personnes).
Les inscriptions doivent se faire sur Eventbrite, comprenant un paiement de 100€ /personne pour les professionnels, ou 35€ / personne pour les étudiants.


 Please note: this is only a pre-program, speakers and presentations are subject to modification.
Cortical connections conference  - 13th June 2019

8:45– 8:50  Welcome Stanislas Lyonnet, Director of Imagine Institute
8:50– 9:00  Introduction to IRC5  Lynn Paul, IRC5 President

Session 1: Brain Development (chair: Elliott Sherr)

9:00-9:20 Linda Richards :   “Mutations in human DCC affect cell morphology which may underlie altered interhemispheric remodelling of the septum and agenesis of the corpus callosum”
9:20-9:40 Alessandra Pierani : "Life and death of transient neurons in the maturation of functional and dysfunctional cortical circuits"
9:40-10:00 Alain Chedotal : “Role of netrin 1 and DCC in axonal wiring: from spinal cord to cortex”
10:00-10:20 Anais Bellon : "Epigenetic control of cortical wiring: role of axonal miRNAs in fetal alcohol spectrum disorders"

10:20-10h:40 Morning Break
Session 2 : Models (chair: Linda Richards)

10:40-11:00 Binnaz Yalcin : “Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis”
11:00-11:20 Marta Nieto Lopez : “Developmental plasticity underlies the diversity of cortical maps”
11:20-11:40 Christine Laclef  : “Role of primary cilia in corpus callosum development”
11:40-12:00 Sonia Garel : “Microglia at the crossroads of cortical wiring and environmental signals"
12:00-12:20 Diego Szczupak: “Assessing interhemispheric connectivity in animal models of dysgenesis of the corpus callosum”

12:20-14:00 - Lunch Break
Session 3:  Connectivity and plasticity (chair: Fernanda Tovar-Moll)

14:00-14:20 Roberto Lent - “Cortical connectivity changes after severe peripheral traumas “
14:20-14:40 Jorge Moll : “Functional Imaging of Social Reward and Moral Motivation”
14:40-15:00 Ghislaine Dehaene: “Corpus callosum and functional hemispheric asymmetries in human infants”
15:00-15:20 Gregor Kasprian : “Clinical Fetal Magnetic Resonance Imaging of Brain Connectivity”

15:20-16:00  Posters flash session (chair : Lynn Paul)
16:00 - 16:20 Afternoon Break
Session 4 : Long-term outcomes (chair : Paul Lockhart)

16:20-16:40 Stéphanie Valence : “Prenatal diagnosis of ACC:  what have they become? Prospective follow-up of a cohort of children born between 2005 and 2015”
16:40-17:00 Romina Romaniello : “Long-term follow-up of a cohort of subjects affected by corpus callosum agenesis detected during fetal life: Neuropsychological, neuroimaging and genetic correlations”
17:00-17:20 Vincent Desportes : “Outcome of isolated agenesis of the corpus callosum: a population-based prospective study”


17h20-17h25 Presentation from Agilent Technlogies

17H30 -19h30 :  Poster session and Welcome Cocktail
Cortical connections conference  - 14th June
Session 5: Prenatal diagnosis (chair: Christel Depienne)

9:00-9:20 Laurent Guibaud : “Prenatal imaging diagnosis of corpus callosum anomalies”
9:20-9:40 Zvi Leibowitz : “The many faces of the fetal corpus callosum, on our experience and difficulties in diagnosing and counselling parents of fetuses with suspected callosal anomalies”
9:40-10:00 Tally Lerman-Sagie : “Autopsy findings in Fetuses with Agenesis of the Corpus Callosum Diagnosed in Utero”
10:00-10:20 Laurent Salomon :  Lumière prenatal research Platform

10:20-10:40  Morning Break
Session 6:Behavior (chair: Warren Brown)

10:40-11:00 Lynn Paul - Behavioural Consequences of Callosal Malformations
11:00-11:20 Jessica Dubois : “Imaging the structural and functional development of brain connectivity”
11:20-11:40 Vanessa Siffredi : “Agenesis of the corpus callosum: Exploring neuroplastic responses in the anterior and posterior commissures”
11:40-12:00 Laurence Vaivre-Douret:  “Patients with ARID1B mutations (Coffin-Siris syndrome): specific neuropsychological and neuropsychomotor deficits correlated with corpus callosum metrics”
12:00-12:20 Alice Wright: “Social cognition: A comparison of Agenesis of the Corpus Callosum and Autism Spectrum Disorder”

12:20 - 14:00 Lunch Break
13:30 Welcome of families
Clinical Applications (with Families) (chair: Marie-Laure Moutard)

14:00-14:20 Catherine Garel: Imagerie prénatale de l’agénésie du corps calleux : interêt et limites / Prenatal imaging of corpus callosum agenesis : interest and limits
14:20-14:45 Tania Attié-Bitach & Solveig Heide : Génétique des anomalies du corps calleux / Genetics of corpus callosum anomalies
14:45-15:00 Delphine Héron : Séquençage d‘exome en prénatal dans les agénésies du corps calleux : résultat d’une étude pilote / Prenatal whole exome sequencing in agenesis of the corpus callosum: a French experience
15:00-15:20 Emmanuelle Lacaze & Kim Giraudat : Aspects cognitifs et psychoaffectifs des enfants suivis pour une agénésie du corps calleux / Cognitive Cognitive and psychoaffective aspects of children followed for agenesis of the corpus callosum
15:20-16:00 Jean-Marie Jouannic : Les grandes étapes du diagnostic prénatal des anomalies calleuses / The main steps of prenatal diagnosis of callosum abnormalities

16:00 - 16:20 Afternoon Break

16:20-16:40 Béatrice Langellier-Bellevue: Prise en charge médico-sociale des agénésies du corps calleux / Medico-social care of corpus callosum agenesis.
16:40-17:00 Laëtitia Domenighetti :  Maladies rares en France et en Europe, intérêt d'une association de patients / Rare diseases in France and Europe, interest of a patient organisation  

17:00- 17:30 round table with families
Concluding Remarks: Linda Richards, PhD, IRC5 Secretary


Tania Attié-Bitach
Hopital Necker/ Université Paris 5 MD, PhD

Anais Bellon
Université Aix-Marseille PhD

Alain Chedotal
Institut de la Vision PhD

Ghislaine Dehaene
INSERM/Neurospin MD, PhD

VD Vincent Desportes
Vincent Desportes
University Hospital HFME, Lyon, France Head of the department of child neurology

Laëtitia Domenighetti
AnDDI-Rares Project manager

JD Jessica Dubois
Jessica Dubois
Inserm Researcher

Catherine Garel
Hopital Armand-Trousseau MD

Sonia Garel
Institut de Biologie de l'Ecole Normale Superieure PhD

Laurent Guibaud
CHU de Lyon Pr

SH Solveig Heide
Solveig Heide

Delphine Heron
La Pitié-Salpétrière Dr

Jean-Marie Jouannic
Hôpital Armand Trousseau Professor

Nathalie Boddaert
Necker Hospital Head of Pediatric Radiology

BB Beatrice Bollaert
Beatrice Bollaert

Rhonda Booth
University of London

Imagine Institute

Tania Attié-Bitach


Thursday 13 June, 08:45 AM

till Friday 14 June 05:30 PM


Imagine Institute 24, Boulevard de Montparnasse Paris FR

Intn'l Research Consortium for the Corpus Callosum & Cerebral Connectivity

  • Event's organizer

The International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5) is an international, multidisciplinary effort to discover the causes, consequences, and effective interventions for disorders of the corpus callosum and associated disorders of cerebral connectivity. It was established on March 20, 2015 by a group of investigators who are leading experts in corpus callosum developmental disorders and their neuropsychological and developmental outcomes and who have main...

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